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Researchers at the University of Colorado Anschutz Medical Campus found a promising therapeutic candidate that could aid in the restoration of vision in those suffering from multiple sclerosis (MS) and other neurodegenerative diseases.
The medicine, LL-341070, improves the brain's ability to repair damaged myelin--the protective sheath that surrounds nerve fibers. Myelin damage is a hallmark of disorders such as MS, as well as a normal consequence of aging, and it frequently causes visual loss, loss of motor abilities, and cognitive decline. The research, focused on vision, demonstrated that while the brain has some ability to repair itself when myelin is damaged, the process can be slow and inefficient. Researchers observed that LL-341070 significantly accelerated the repair process and improved brain function related to vision in mice, even after severe damage. "This research brings us closer to a world where the brain has the capacity to heal itself" said Ethan Hughes, PhD, co-lead author and associate professor in the Department of Cell and Developmental Biology at the CU School of Medicine. "By harnessing this potential, we hope to help people with diseases like MS by potentially reversing some of the damage, offering people the opportunity to regain their vision and cognitive function." Researchers discovered that the treatment makes the repair process much more effective following serious damage, highlighting the importance of intervention with severe injury. Even partial repair of myelin was found to significantly improve vision-related brain functions. "We've known for years that myelin plays a crucial role in brain function," said Daniel Denman, PhD, co-lead author of the study and assistant professor in the Department of Physiology and Biophysics at the CU School of Medicine. "This study highlights the role of cortical myelin in visual function. The drug could be a game-changer because it accelerates the brain's natural repair mechanisms." The researchers plan to test the drug in other areas of the brain and refine the treatment, hoping to make it even more effective and eventually accessible to patients. "This discovery is just the beginning," Hughes said. "We are optimistic that LL-341070 and similar therapies could one day provide real, tangible benefits to patients by improving overall brain function and quality of life." (ANI)
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