Wednesday, February 12, 2025
News

Potential new therapy could soon help those who have cancer-related fatigue

   SocialTwist Tell-a-Friend    Print this Page   COMMENT

Connecticut | October 8, 2023 6:16:18 PM IST
Cancer-related fatigue (CRF) affects patients' quality of life while they are undergoing treatment and is a debilitating yet all-too-common condition. For the constellation of symptoms that make up CRF, there are currently no effective pharmaceutical treatments.

In a new study led by Yale Cancer Center researchers at Yale School of Medicine, the team found that a metabolism-targeting drug called dichloroacetate (DCA) helped alleviate CRF in mice, without interfering with cancer treatments. The findings are a pathway for future CRF research that may someday lead to a new therapy for patients.

The results were published in American Journal of Physiology-Endocrinology and Metabolism on October 2.

"This study identifies dichloroacetate, an activator of glucose oxidation, as the first intervention, and particularly the first metabolism-focused intervention, to prevent the whole syndrome of cancer-related fatigue in preclinical models," said senior author Rachel Perry, who is a member of Yale Cancer Center.Researchers used tumour-bearing mouse models to investigate the effectiveness of DCA in treating cancer-related fatigue for patients living with melanoma.

The group found that DCA did not affect the rates of tumour growth or compromise the effectiveness of immunotherapy or chemotherapy in two mouse cancer models. DCA also significantly preserved physical function and motivation in mice with late-stage tumours.

The data suggests that DCA treatment may have several positive effects, including reducing oxidative stress in muscle tissue of tumor-bearing mice. The researchers said DCA could be a practice-changing approach in the future, when used as an adjuvant therapy to treat cancer-related fatigue.

"We hope that this research will provide the bedrock for future clinical trials using dichloroacetate -- an FDA-approved drug for another indication (lactic acidosis) -- to treat the debilitating syndrome of cancer-related fatigue," said Perry, who is also an assistant professor of medicine (endocrinology) and of cellular and molecular physiology at Yale School of Medicine. (ANI)

 
  LATEST COMMENTS ()
POST YOUR COMMENT
Comments Not Available
 
POST YOUR COMMENT
 
 
TRENDING TOPICS
 
 
CITY NEWS
MORE CITIES
 
 
 
MORE HEALTH NEWS
Study uses clues from body to understand...
Some species are susceptible to broad ra...
More...
 
INDIA WORLD ASIA
Maha Kumbh's Magh Purnima 'snan' conclud...
CM Yogi convenes meeting to monitor Magh...
Prayagraj: Flower petals showered on dev...
Assam police apprehend member of Manipur...
'BJP a workers-based party, national lea...
UP CM Yogi Adityanath expresses condolen...
More...    
 
 Top Stories
Shikhar Dhawan opens up on playing ... 
The Future of Innovation: Leaders &... 
"Domestic cricket is important, but... 
Pet Care Startup Supertails Brings ... 
An Exclusive Evening with Gauri Kha... 
LaRiSa Hotels & Resorts and AM ... 
Boney Kapoor, Arjun Kapoor meet Odi... 
Alite's V-Day Campaign: Encouraging...