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Despite the broad acceptance of screening initiatives in several high-income European nations, colorectal cancer rates remain high. Most people are screened starting at the same age in these initiatives, which tend to utilise a one-size-fits-all approach without taking individual circumstances into account.
Researchers from Finland have now described how common genetic factors could be used to identify people at high risk of acquiring the disease and, as a result, enhance current colorectal screening procedures. This is based on one of the largest genomics studies on the subject to date. Max Tamlander, MD at the Institute for Molecular Medicine Finland (FIMM) of the University of Helsinki, will present to the annual conference of the European Society of Human Genetics today (Monday 12 June) his team's work on the development of a polygenic risk score (PRS) specifically for colorectal cancer. A PRS summarises the combined impact of an individual's genetic risk factors for disease into a single score. This allows an estimation of an individual's likely disease risk and the identification of those who might benefit from earlier screening. The researchers used data from the FinnGen study, a collection of health and genome data from more than 400,000 Finnish individuals, for which they calculated a genome-wide PRS for colorectal cancer. "A challenge of many prior PRS studies is that they have been performed in smaller datasets that are not representative of the general population, but in this study, we used epidemiological and statistical approaches to calibrate our estimates with that population," Dr Tamlander explains. Most cases of colorectal cancer occur in individuals who do not have a family history of the disease or any other known strong risk factors. PRSs offer a new way of assessing risk in these individuals, which until now has been based on attained age alone. The researchers' results also show that a PRS could be useful in the assessment of future colorectal cancer risk after a colonoscopy, the current gold-standard screening method, and identifying those individuals who would potentially benefit from more frequent surveillance. In Finland, screening for colorectal cancer in the general population currently starts at age 60; in some other European countries, it starts earlier, from 50. The researchers found that, based on the current screening age of 60 in Finland, individuals with a high PRS as compared to those with a low PRS could start screening up to 16 years apart. For example, women and men in the top 1 per cent of the PRS already had equivalent risks at ages 48.7 and 49.8, respectively. "This indicates that a colorectal cancer-specific PRS would be able to define more appropriate ages to start screening for individuals based on their genetic risk," says Dr Tamlander. As the cost of genotyping continues to fall, PRS-based approaches may become a feasible way to guide population-wide screening. "Millions of individuals already have their genomes available in large-scale biobanking initiatives," says Dr Tamlander. "For example, the FinnGen biobank study already contains the genomic data of over 7 per cent of all Finns, and this will soon increase to around 10 per cent. One very useful aspect of PRSs is that genetic data extracted from a single sample can be used over the course of life to calculate risk scores for many common diseases, including the most common cancers." Further clinical studies as well as data on cost-effectiveness and the effective communication of risk information will be needed before large-scale implementation of the colorectal PRS, say the researchers. Another problem is that, to date, PRS have been mainly developed in individuals of European descent, and therefore may not be valid for people of other ancestries. "However, our findings are well in line with other studies on PRSs in breast cancer, another common cancer with organised population-level screening. For breast cancer, large clinical trials are currently underway to evaluate the performance of personalised breast cancer screening, and their results will help us to understand the implications of genome-guided, risk-based screening for colorectal cancer, as well as other diseases," Dr Tamlander continues. "In the future, risk-based approaches considering genetic factors alongside other relevant risk factors have the potential for personalising recommendations regarding how we could most effectively screen for colorectal cancer," Dr Tamlander will conclude. Professor Alexandre Reymond, chair of the conference, said, "Recognising the individuals who are at risk is fundamental if our health systems want to truly embrace personalised health in the future." (ANI)
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