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A new study by UCL researchers reveals that conditions, including celiac disease and Parkinson's disease, could be recognised up to ten years sooner than they are now.
The study, published in the British Journal of General Practice, reviewed existing evidence on how people's use of healthcare changed in the weeks, months and years ahead of the diagnosis of a range of conditions. This detectable change in healthcare use indicates the condition's "diagnostic window" -- that is, the point at which diagnosis in some patients may theoretically be possible. While the concept of diagnostic windows has been developed in cancer research, this study comprehensively examines whether it is relevant for other diseases for the first time. The review, led by PhD candidate Emma Whitfield (UCL Institute of Epidemiology & Health Care and UCL Institute of Health Informatics), looked at 27 studies containing evidence of how healthcare use changed among people who went on to be diagnosed with a condition. It found that for chronic conditions such as Parkinson's disease, coeliac disease, schizophrenia, and inflammatory bowel disease (including ulcerative colitis and Crohn's disease), healthcare use increased years before diagnosis, suggesting significantly earlier diagnosis might be possible for some patients. For relatively acute onset conditions such as tuberculosis and herpes simplex encephalitis (infection caused by the herpes simplex virus), the change in healthcare use occurred only shortly before diagnosis -- between 1 and 6 months. Lead author Ms Whitfield said: "In the last 20 years, researchers have put much time and effort into improving the diagnosis of cancer. A body of literature has built up with novel concepts, such as the 'diagnostic window', that haven't been comprehensively applied to other diseases, and this was the motivation for our study. "The next step is to analyse comprehensive datasets to determine the length of these diagnostic windows with more certainty," she said, adding, "More detailed information about the type of changes in healthcare use before diagnosis can provide new avenues for inquiry as to how earlier diagnosis might be achieved." "This initial evidence suggests that, if improvements can be made to the diagnostic process, there is potential to diagnose some patients with these conditions earlier," she added. (ANI)
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