Wednesday, January 15, 2025
News

Hypertension medications may be used to slow ageing process: Research

   SocialTwist Tell-a-Friend    Print this Page   COMMENT

Washington | January 28, 2023 2:33:41 PM IST
Researchers discovered that the drug rilmenidine can extend life and slow down the ageing process.

Published in Aging Cell, the findings show that animals treated with rilmenidine, currently used to treat hypertension, at young and older ages increases lifespan and improves health markers, mimicking the effects of caloric restriction.

They also demonstrate that the healthspan and lifespan benefits of rilmenidine treatment in the roundworm C. elegans are mediated by the I1-imidazoline receptor nish-1, identifying this receptor as a potential longevity target.

Unlike other drugs previously studied for this purpose by the researchers, the widely-prescribed, oral antihypertensive rilmenidine has potential for future translatability to humans as side-effects are rare and non-severe.

To date, a caloric restriction diet has been considered the most robust anti-aging intervention, promoting longevity across species. However, studies of caloric restriction in humans have had mixed results and side effects, meaning finding medications like rilmenidine that can mimic the benefits of caloric restriction is the most reasonable anti-aging strategy.

Professor Joao Pedro Magalhaes, who led the research whilst at the University of Liverpool and is now based at the University of Birmingham, said: "With a global ageing population, the benefits of delaying ageing, even if slightly, are immense. Repurposing drugs capable of extending lifespan and healthspan has a huge untapped potential in translational geroscience. For the first time, we have been able to show in animals that rilmenidine can increase lifespan. We are now keen to explore if rilmenidine may have other clinical applications." (ANI)

 
  LATEST COMMENTS ()
POST YOUR COMMENT
Comments Not Available
 
POST YOUR COMMENT
 
 
TRENDING TOPICS
 
 
CITY NEWS
MORE CITIES
 
 
 
MORE HEALTH NEWS
Bioengineers found breakthrough in build...
Fibre in diet may boost the body against...
Research discovers new skeletal tissue w...
Revolutionizing Hip Replacement Surgery:...
Mrs. Neerja Birla Initiative Mpower Stre...
Gujarat health minister issues advisory ...
More...
 
INDIA WORLD ASIA
From IIT Bombay to Spiritual Heights: Ba...
Congress' Ramesh Chennithala urges Jaish...
PM Modi emplanes for Mumbai, will dedica...
Delhi Court acquits husband, brother-in-...
'AAP, Congress complementary to each oth...
Ghaziabad: Police launch anti-encroachme...
More...    
 
 Top Stories
Shikhar Dhawan opens up about chall... 
BSF recovers Pakistani drone with o... 
UP CM Yogi issues directives to acc... 
"Grave risks faced by individuals e... 
INS Vagsheer commissioned into Indi... 
Bangladesh will work with global pa... 
Global manufacturer of lithium-ion ... 
BJP releases star campaigner list f...