Study: Long reproductive span, older age at menopause associated with lower dementia risk

The results of the study were published in the journal, 'PLOS Medicine'.

It suggested that reproductive and hormonal factors may be involved in dementia risk, but observed a similar association between the number of children and dementia risk in women and men, suggesting that the physical experience of childbearing may not account for risk variation.

Dementia rates are increasing around the world, with some studies reporting a higher incidence in women than men, yet there is limited evidence-based on reproductive factors and the risk of dementia. Jessica Gong and colleagues used the data to examine the risk of all-cause dementia and reproductive factors in 273,240 women as well as the number of children in those women and in 228,965 men.

After controlling for age, socioeconomic status, smoking, body mass index (BMI), and other elements, certain events related to shorter cumulative exposure to internally produced estrogen -- such as older than the average age at first period, younger than the average age at menopause, and having a hysterectomy -- were associated with higher dementia risk.

Pregnancy, even aborted pregnancy, longer reproductive span, older age at menopause, and use of contraceptive pills were associated with a lower risk of all-cause dementia. For both men and women, compared with having two children, having no children or four or more were apparently associated with a greater risk of dementia.

The study has limitations including the retrospective reporting on reproductive factors that can be subject to bias, and the fact that UK Biobank is a relatively healthy cohort of affluent people of white British ancestry so may not be representative of a broader population.

Gong concluded, "Reproductive events related to shorter exposure to endogenous estrogen in women were associated with higher dementia risk, and these findings highlight the vulnerability in dementia risk pertaining to women. However, the similar association between the number of children and dementia risk observed for women and men indicates that the risk variation in women may be more related to social and behavioural factors in parenthood, rather than biological factors involved in childbearing." (ANI)