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Within the next ten years, obesity--which has been connected to dementia and cognitive decline--is predicted to impact up to half of the population in the US.
Two years after undergoing bariatric surgery, researchers at Michigan Medicine found that stable cognition was maintained in obese patients. The researchers found that bariatric surgery may slow the progression of cognitive impairment in persons who are fat. The results are published in the Journal of Nutrition, Health & Aging. "Since individuals with obesity experience more rapid cognitive decline than those without, stable cognition two years after bariatric surgery may be considered a success against historical trends, yet future controlled trials are needed to test this," said first author Evan Reynolds, Ph.D., lead statistician for the NeuroNetwork for Emerging Therapies at Michigan Medicine. Using a collection of memory and language tests developed by the National Institutes of Health, as well as the Rey Auditory Verbal Learning Test, the research team assessed over 85 bariatric surgery patients at two-year follow up. They found that NIH Cognitive Battery test scores remained stable, with secondary executive function tests showing improvement. One of the memory assessments, however, declined following surgery. While this current study is the largest to assess changes two years after bariatric surgery, researchers say, the results conflict with previous studies which found improved memory and executive functioning among similar patients. "That study was primarily made up of patients who received gastric bypass, while our study was made up primarily of individuals that completed a sleeve gastrectomy," Reynolds said. "To provide the best evidence on the effectiveness of bariatric surgery on cognition and potential differences between surgery types, we must conduct larger observational studies or randomized, controlled trials." After bariatric surgery, improvements in diabetes complications, such as peripheral neuropathy, chronic kidney disease and retinopathy, were not associated with improved cognition. "Metabolic factors, including diabetes and obesity, are associated with cognitive decline, but we still need to better understand how best to treat these factors to improve patients' cognitive outcomes," said senior author Brian Callaghan, M.D., a neurologist at University of Michigan Health and the Eva L. Feldman., M.D, Ph.D., professor of neurology at U-M Medical School. (ANI)
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