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The brain's immune cells, known as microglia, have been shown to cause cognitive abnormalities following radiation exposure. Microglia may be a crucial target for mitigating these symptoms, revealed a new research by the University of Rochester's Del Monte Institute for Neuroscience.
These results, which were published in the International Journal of Radiation Oncology Biology Biophysics, add to earlier studies that demonstrated microglia, which are responsible for the destruction of synapses, the connections between neurons crucial for memory and cognitive function, following radiation exposure. "Cognitive deficits after radiation treatment are a major problem for cancer survivors," M. Kerry O'Banion, MD, PhD, professor of Neuroscience, member of the Wilmot Cancer Institute, and senior author of the study said. "This research gives us a possible target to develop therapies to prevent or mitigate against such deficits in people who need brain radiotherapy." Using several behavioral tests, researchers investigated the cognitive function of mice before and after radiation exposure. Female mice performed the same throughout, indicating a resistance to radiation injury. However, researchers found male mice could not remember or perform certain tasks after radiation exposure. This cognitive decline correlates with the loss of synapses and evidence of potentially damaging microglial over-reactivity following the treatment. Researchers then targeted the pathway in microglia important to synapse removal. Mice with these mutant microglia had no cognitive decline following radiation. And others that were given the drug, Leukadherin-1, which is known to block this same pathway, during radiation treatment, also had no cognitive decline. "This could be the first step in substantially improving a patient's quality of life and need for greater care," said O'Banion. "Moving forward, we are particularly interested in understanding the signals that target synapses for removal and the fundamental signaling mechanisms that drive microglia to remove these synapses. We believe that both avenues of research offer additional targets for developing therapies to help individuals receiving brain radiotherapy." O'Banion also believes this work may have broader implications because some of these mechanisms are connected to Alzheimer's and other neurodegenerative diseases. (ANI)
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