Researchers develop technique for bladder transplantation in humans

As reported in the October issue ofThe Journal of Urology, an Official Journal of theAmerican Urological Association(AUA). The journal is published in the Lippincott portfolio byWolters Kluwer.

"Our study is the first report of bladder auto-transplantation in heart-beating, brain-dead human research donors as a necessary preparatory step toward clinical bladder transplantation in living patients," comments Inderbir S Gill, MD, of Keck School of Medicine, University of Southern California, Los Angeles.

Human urinary bladder transplantation has never been carried out before, despite the fact that transplantation is a recognised treatment for many types of organ failure. That is due in part to the tough technical difficulties involved in such an operation, such as the challenging anatomy of the deep pelvis and the difficult surgical access to that region's blood arteries.

Patients with terminal bladder conditions which render the bladder unusable may undergo surgery to remove the bladder (cystectomy).

This is followed by some type of diversion procedure to restore urinary function, typically using a segment of the patient's own bowel tissue. Although these reconstructive procedures have a high success rate, they carry a substantial risk of short- and long-term complications.

Dr Gill and his team, including Dr Nima Nassiri, performed a series of fundamental pre-clinical studies to develop the technique of robotic bladder transplantation.

Their experience included three models of auto-transplantation removing the bladder and associated tissues, including arteries, veins, and ureters; preparing it as if from a human donor; and transplanting the prepared organ back into the donor.

Techniques developed in the animal and cadaver models were successfully applied to the beating heart donors. In all three models, operative times for robotic auto-transplantation decreased with experience. In the beating-heart donors, total surgical time decreased from 10.5 to 4.7 hours.

Bladder transplant could be a 'viable treatment option' for selected patients

Three out of four attempts at robotic auto-transplantation in beating-heart donors were successful, resulting in good blood flow to the transplanted bladder. In one case, the donor was maintained on life support for 12 hours to confirm the continued viability of the transplanted bladder.

Compared to open surgery, the robotic approach was felt to significantly facilitate donor cystectomy (bladder removal) surgery because of its superior technical access to the deep pelvis and blood vessel control.

The online version of the article includes a link to a video where urologists can view key steps of the robotic auto-transplantation technique. Based on this rigorous pre-clinical developmental work, Dr. Gill and colleagues are preparing for the initial feasibility clinical trial of human bladder transplantation.

If the technique of bladder transplantation can be successfully developed and refined, it could become "a viable treatment option in a minority of well-selected and well-counseled patients," the researchers conclude.

They emphasize the many unanswered questions that remain including the long-term functioning of the transplanted bladder, the need for lifelong immunosuppressive therapy to prevent organ rejection, and patient acceptance of bladder transplant versus standard urinary diversion procedures. (ANI)