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A pacemaker is a small device that's placed (implanted) in the chest to help control the heartbeat. It's used to prevent the heart from beating too slowly. A recent study has elaborated on a revolutionary pacemaker, that re-established the heart's naturally irregular beat.
Manaaki Manawa, the Centre for Heart Research at the University of Auckland led the research and the results have been published in journal, 'Basic Research in Cardiology'. The revolutionary pacemaker is set to be trialled in New Zealand heart patients this year, following successful animal trials. "Currently, all pacemakers pace the heart metronomically, which means a very steady, even pace. But when you record heart rate in a healthy individual, you see it is constantly on the move," said Professor Julian Paton, a lead researcher and director of Manaaki Manawa. "If you analyse the frequencies within your heart rate, you find the heart rate is coupled to your breathing. It goes up on inspiration, and it goes down on expiration, and that is a natural phenomenon in all animals and humans. And we're talking about very ancient animals that were on the planet 430 million years ago." Twelve years ago, Paton was a member of a group of scientists who decided to investigate the function of this variability. They made a mathematical model that predicted it saved energy. That made them question why a metronomic heartbeat was used in heart-failure patients who lacked energy. They asked, "Why aren't we pacing them with this variability?" All cardiovascular disease patients lose the heart rate variability, which is an early sign that something is going wrong. "People with high blood pressure, people with heart failure, their heart rate is not being modulated by their breathing. It may be a little bit, but it's very, very depressed, very suppressed," Paton said. "We decided that we would put the heart rate variability back into animals with heart failure and see if it did anything good." Following positive signals in rats, the latest published research was on a large animal model of heart failure, performed by Dr Julia Shanks and Dr Rohit Ramchandra. "And the big news is that we believe we have now found a way to reverse heart failure," Dr Ramchandra said. Dr Julia Shanks, the research fellow who carried out the research, explained, "There's nothing really on the market that will cure heart failure. All the drugs will do is make you feel better. They don't address the issue that you've got damaged tissue that's not contracting as efficiently as it was. Our new pacemaker brings back this variability, which of course is natural, in a way you could call it 'nature's pacemaker'." Dr Ramchandra said, "Currently, pacemakers trigger a metronomically steady beat, but this study shows introducing a natural variation in the heartbeat improves the heart's ability to pump blood through the body. The other big news is that we get a 20 percent improvement in cardiac output, which is effectively the ability of the heart to pump blood through the body. And 20 percent is a big number." "The pacemaker is almost like a bionic device," said Paton. "It understands the signals from the body that tell the device when we're breathing in and when we're breathing out. And then the device has to communicate back to the body and pace the heart up during breathing in and down during breathing out." On seeing the results, interventional cardiologist Dr Wil Harrison from Middlemore Hospital in Auckland remarked: "Very interesting study. We do recognise clinically that permanent pacing is 'non-physiological' to a certain degree, and pacing-induced cardiomyopathy is a well-recognised phenomenon. It will be exciting to see if the findings translate over to humans." Dr Martin Stiles, a cardiologist from Waikato Hospital, in Hamilton, New Zealand, who will lead the trial said: "We typically see improvements in heart function with current pacemakers, but this bionic pacemaker has far exceeded our expectations. This discovery may revolutionise how heart failure patients are paced in the future." (ANI)
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