Wednesday, May 18, 2022
News

Heart disease causes early brain dysfunction, may treble key Alzheimer's protein: Study

   SocialTwist Tell-a-Friend    Print this Page   COMMENT

Washington | January 20, 2022 6:20:53 PM IST
A new research has found that heart disease causes a breakdown of a key brain function which links brain activity and blood flow.

The study has been published in the 'eLife Journal'.

This is happening in heart disease patients before the build-up of fat in the brain's blood vessels (atherosclerosis) and is a prelude to dementia. Until now, it has been unclear how some forms of vascular dementia can happen years before atherosclerosis in the brain.

The researchers also discovered that the combination of heart disease and a genetic predisposition for Alzheimer's disease trebles the amount of beta-amyloid, a protein that builds up and triggers Alzheimer's, and increases the levels of an inflammatory gene (IL1) in the brain.

Dr Osman Shabir, the lead author of the study from the University of Sheffield's Neuroscience and Healthy Lifespan Institutes, said, "Alzheimer's disease is the most common form of dementia worldwide and heart disease is a major risk factor for both Alzheimer's and dementia. The new findings are key to furthering our understanding of the links between heart disease and dementia."

"We've discovered that heart disease in midlife causes the breakdown of neurovascular coupling, an important mechanism in our brains which controls the amount of blood supplied to our neurons. This breakdown means the brain doesn't get enough oxygen when needed and in time this can lead to dementia," he added.

The team also found that brain injuries can also worsen brain blood flow regulation, supporting observations that patients' symptoms often worsen after injuries or falls. (ANI)

 
  LATEST COMMENTS ()
POST YOUR COMMENT
Comments Not Available
 
POST YOUR COMMENT
 
 
TRENDING TOPICS
 
 
CITY NEWS
MORE CITIES
 
 
 
MORE SCIENCE NEWS
Reseachers finds imbalance between energ...
Here's how greenhouse gas emissions can ...
Bezos' Blue origin targets May 20 for ne...
Study suggests some strategies to cut me...
Research suggests soil from moon can gen...
Scientists identify how brain triages em...
More...
 
INDIA WORLD ASIA
K'taka: BJP, Cong lock horns over arms t...
Gujarat BJP's call to adopt malnourished...
SC orders protection of 'Shivling' found...
Raj Thackeray won't be allowed to enter ...
Delhi govt plans to increase roadside gr...
J-K: Vomedh celebrates 14th foundation d...
More...    
 
 Top Stories
Zuper Hotel Solutions inks manageme... 
Historical friendship and strong co... 
Truecaller launches mobile app grow... 
A Resilient and Sustainable Energy ... 
Cong MP says Hardik Patel's allegat... 
UK's healthcare 'dangerously relian... 
Fourth edition of Saquib Rizvi Memo... 
Global Chamber of Business Leaders ...