Friday, October 2, 2020
Cambridge Isotope Laboratories, Inc. Announces Expansion of 13C Capacity at Ohio Plant
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TEWKSBURY, Massachusetts, Aug. 12, 2020 /PRNewswire/ --  Cambridge Isotope Laboratories, Inc.  (CIL),  the  world leader in stable isotope chemistry and the separation of  carbon-13 (13C),  recently completed a significant expansion of its  13C  separation facility.  In 1987,  CIL took the initiative to construct the world's  largest 13C isotope-separation plant, Cambridge Isotope Separations, LLC (CIS), located  on 33 acres  in Xenia, Ohio.13C is a critical starting material supporting development of new research and diagnostic chemicals.    Following expansions in 1996,  2012,  and 2015, CIL embarked on a new expansion  in 2018 which was completed earlier this year.  This most recent expansion increased production capacity of  13C by 25%.

"CIL  has been investing and growing with customers continuously for  the past 33 years," states Cliff Caldwell, CEO.  "Our  isotope  markets have been expanding,  and the volumes required  by our committed customers  have made it necessary that we  continue to expand to  meet the market needs.  Cambridge Isotope  Labs  has many years of experience designing and building carbon isotope-separation  systems and we are the leading technology expert in that space.  This  in-house  knowhow makes us the supplier of choice  because of the certainty we  can reliably scale  our production processes quickly and effectively."

"The expansion was initiated in response to the strong and growing demand by our customers for  13C and  13C urea," says  Mike  Steiger, VP of Project Engineering and Execution. "There is an increasing need for isotopes for medical investigations and  13C plays an important role."  The  13C isotope is known to be used in a variety of applications for environmental analysis, medical research,  and medical diagnostics.  Medical  diagnosis-based CO2  breath  tests,  such as  13C urea  (used to detect  Helicobacter pylori  bacterial  infection)  and  13C  methacetin  for liver disease,  can  aid  in the  prevention of invasive procedures.

13C is a nonradioactive (stable) element which makes up approximately 1% of all carbon atoms in nature. At the CIS  plant in Ohio, natural carbon monoxide (containing ~1% 13C) is cryogenically liquefied and then distilled through several long specially designed distillation columns, which make it one of the world's longest distillation systems of any kind.  CIL has continuously demonstrated its expertise in the area of cryogenic distillation and maintain our place as the world's leading producer  of  13C isotope.  The end-product of this process is carbon monoxide that is greater than 99% 13C, which  is then used to manufacture any one of the thousands of isotope-labeled products offered by CIL.

About Cambridge Isotope Laboratories, Inc.   

CIL is the world's largest manufacturer and global supplier of stable isotopes and stable isotope-labeled compounds used in research, environmental, neonatal, pharmaceutical, medical diagnostic, OLED, and industrial markets. CIL is an operating business owned by Otsuka Pharmaceuticals. The CIL business consists of two facilities in the Boston, MA, area; a large isotope-enrichment production plant in Xenia, OH; CIL China; CIL Canada; ABX in Dresden, Germany; and Eurisotop in Saclay, France.   

For more information on CIL, visit

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