Wednesday, April 21, 2021
News

New oral drug can stop tumours from growing

   SocialTwist Tell-a-Friend    Print this Page   COMMENT

New York | Thursday, 2021 11:15:06 PM IST
US researchers have found that an oral drug can be effective in stopping tumours from growing.

The team from the University of Colorado Cancer Center found that slowing down NLRP3 can reduce inflammation and curb tumour growth and progression.

"NLRP3 is a member of a larger family that is involved in sensing danger signals," said Carlo Marchetti, from the varsity's School of Medicine.

"It is a receptor that surveils the intercellular compartment of a cell, looking for danger molecules or pathogens.

"When NLRP3 recognises these signals, it leads to the activation of caspase-1, a protein involved in the processing and maturation of interleukin-1-beta into its biological active form, causing an intense inflammatory response. We found that in melanoma, this process is dysregulated, resulting in tumour growth," Marchetti said.

The study is published in the journal PNAS.

The oral NLRP3 inhibitor used in the study (Dapansutrile) has already shown to be effective in clinical trials to treat gout and heart disease, and it is currently being tested in Covid-19 as well.

The researchers are now trying to find out if this NLRP3 inhibitor can be successfully used in melanoma patients who are resistant to checkpoint inhibitors.

"Checkpoint inhibitors increase the efficacy of the immune system to kill tumours, but sometimes tumours become resistant to this treatment," Marchetti said.

"A big part of cancer research now is to find therapies that can be combined with checkpoint inhibitors to improve their efficacy," he noted.

--IANS rvt/vd

( 255 Words)

2021-04-08-17:10:04 (IANS)

 
  LATEST COMMENTS ()
POST YOUR COMMENT
Comments Not Available
 
POST YOUR COMMENT
 
 
TRENDING TOPICS
 
 
CITY NEWS
MORE CITIES
 
 
 
MORE HEALTH NEWS
J&K sees highest single-day spike of 2,0...
No plan to impose lockdown in Kashmir: D...
Brazilian Covid-19 variant much more tra...
Maha cancels SSC exams as ministers call...
Andhra logs 8,987 infections, active tal...
Vedanta offers to supply oxygen from its...
More...
 
INDIA WORLD ASIA
Excess money, little education highlight...
Kapil, Sachin, Virat among 5 greatest pl...
10,055 more corona positive cases detect...
Cabinet approves amendments to Finance B...
K'taka cancels examinations for Class 1-...
EC to deploy 779 companies of central fo...
More...    
 
 Top Stories
108 ambulances serving people in J&... 
Gaurav Gera: A hit changes your lif... 
EC to deploy 779 companies of centr... 
Draw inspiration from Federer: Olym... 
4 more Covid related deaths take to... 
Kerala CM writes to PM for change i... 
For Russia with love: Goa beach to ... 
Delhi Police sets up green corridor...