Wednesday, October 23, 2019
News

Study identifies new target to prevent, treat alcoholism

   SocialTwist Tell-a-Friend    Print this Page   COMMENT

| February 9, 2019 6:41:40 PM IST
A new research now identifies a gene that could provide a new target for developing medication to prevent and treat alcoholism.

Scientists at the Oregon National Primate Research Center at OHSU discovered a gene that had lower expression in the brains of nonhuman primates that voluntarily consumed heavy amounts of alcohol compared with those that drank less.

The study was recently published online in the journal Neuropsychopharmacology.

Notably, the research team unravelled a link between alcohol and how it modulated the levels of activity of this particular gene.

Researchers discovered that when they increased the levels of the gene encoded protein in mice, they reduced alcohol consumption by almost 50 per cent without affecting the total amount of fluid consumed or their overall well-being.

The study modified the levels of the protein encoded by a single gene - GPR39 - which is a zinc-binding receptor previously associated with depression.

Using a commercially available substance that mimics the activity of the GPR39 protein, the researchers found that targeting this gene dramatically reduced alcohol consumption in mice.

"The study highlights the importance of using cross-species approaches to identify and test relevant drugs for the treatment of alcohol use disorder," said senior author Rita Cervera-Juanes.

To determine whether the same mechanism affects people, this team of researchers is now examining postmortem tissue samples from the brains of people who suffered from alcoholism.

Currently, there are only a handful of treatments for alcoholism approved by the Food and Drug Administration. By testing the effect of the substance in reducing ethanol consumption in mice - in addition to its previously reported link in reducing depression-like symptoms - the findings may point the way toward developing a drug that both prevents and treats chronic alcoholism and mood disorders in people. (ANI)

 
  LATEST COMMENTS ()
POST YOUR COMMENT
Comments Not Available
 
POST YOUR COMMENT
 
 
TRENDING TOPICS
 
 
CITY NEWS
MORE CITIES
 
 
 
MORE HEALTH NEWS
Researchers uncover factors which affect...
Blood pressure medication works best whe...
Pancreatic, colorectal cancer up 10% in ...
Assam to implement two-child norm from 2...
Immune cells rewire, repair brain while ...
In a first, 26-yr-old DMD patient in UP ...
More...
 
INDIA WORLD ASIA
10 IAS transferred/promoted in major bur...
Position of Governor weak, can't speak ...
J-K: Police identifies three terrorists ...
K'taka: 4 ADGPI teams intensify relief o...
Zakir Musa's successor among three terro...
Delhi: Man arrested in possession of aro...
More...    
 
 Top Stories
IAF chief leaves for Oman to witnes... 
Hero MotoCorp revenue, profit fall ... 
December 18 confirmed as new date f... 
CBI registers FIR against ex-Uttara... 
Sourav Ganguly takes over as BCCI c... 
Delhi's snatcher gang wanted in 90 ... 
RSS chief's 5-day workshop for saff... 
Abdelkarim Hassan handed 5-month su...