Thursday, February 21, 2019
News

Manipulating gut bacteria may cut obesity, diabetes risk

   SocialTwist Tell-a-Friend    Print this Page   COMMENT

New York | Wednesday, 2018 5:15:04 PM IST
Manipulating levels and ratios of gut bacteria can help prevent obesity and diabetes -- a common risk factor for developing cardiovascular diseases, finds a new study.

The study with the rodent equivalent of metabolic syndrome showed evidence that the intestinal microbiome -- a 'garden' of bacterial, viral and fungal genes -- plays a substantial role in the development of obesity and insulin resistance in mammals, including humans.

"This study adds to our understanding of how bacteria may cause obesity, and we found particular types of bacteria in mice that were strongly linked to metabolic syndrome," said David Hackam, researcher at the Johns Hopkins Children's Centre in Baltimore, the US.

"With this new knowledge we can look for ways to control the responsible bacteria or related genes and hopefully prevent obesity in children and adults," he added, in a paper published in the journal Mucosal Immunology.

Metabolic syndrome is a cluster of conditions including obesity around the waist, high blood sugar and increased blood pressure, and is a risk factor for heart disease, stroke and diabetes.

The team ran a series of experiments on both normal mice and mice genetically modified to lack Toll-like receptor 4 (TLR4)-- a protein that receives chemical signals to activate inflammation -- in their intestinal epithelium.

They fed both groups of mice "standard chow," or food with 22 per cent fat calories, for 21 weeks.

Compared to normal mice, those lacking TLR4 showed a series of symptoms consistent with metabolic syndrome, such as significant weight gain, increased body and liver fat, and insulin resistance.

When administered antibiotics there was a significant reduction in the amount of bacteria in the intestinal tract, which prevented all symptoms of metabolic syndrome in the mice that lacked TLR4.

This demonstrates that bacterial levels can be manipulated to prevent the development of metabolic syndrome.

"Our experiments imply that the bacterial sensor TLR4 regulates both host and bacterial genes that play previously unrecognised roles in energy metabolism leading to the development of metabolic syndrome in mice," Hackam said.

--IANS ng/rt/nks/bg

( 346 Words)

2018-02-14-16:42:08 (IANS)

 
  LATEST COMMENTS (0)
POST YOUR COMMENT
Comments Not Available
 
POST YOUR COMMENT
 
 
TRENDING TOPICS
 
 
CITY NEWS
MORE CITIES
 
 
 
MORE HEALTH NEWS
Nuts can keep diabetics' heart healthy...
Bengali singer Pratik Choudhury passes a...
Mexico urges US to do more to discourage...
More interacting key to keeping older ad...
Boost HPV screening, vaccines to end cer...
Common heartburn drug linked to kidney d...
More...
 
INDIA WORLD ASIA
Hyderabad: Madrasas hold protest condemn...
Shimla: Snowfall in Kufri, Chharabra dis...
BJP politicising Pulwama terror attack: ...
Amit Shah to launch BJPs beneficiaries ...
J-K: Community bunkers being made forsa...
Maharashtra: Farmers begin Nashik to Mum...
More...    
 
 Top Stories
Fire kills at least 45 in Banglades... 
Girl in China climbs through train ... 
Alabama woman who joined IS should ... 
US President Trump likely to visit ... 
Iraqi PM, Saudi king discuss boosti... 
UK revokes citizenship of teen who ... 
BJP politicising Pulwama terror att... 
Venezuela's Guaido calls for demons...