Sunday, April 22, 2018
News

This human heart-muscle patch can boost heart attack recovery

   SocialTwist Tell-a-Friend    Print this Page   COMMENT

New York | Saturday, 2018 2:45:04 PM IST
 
Novel heart-muscle patches made with human cells can significantly improve recovery from a heart attack, results of a clinical trial show.

The results are a step closer to the goal of treating human heart attacks by suturing cardiac-muscle patches over an area of dead heart muscle in order to reduce the pathology that often leads to heart failure, said scientists led by Jianyi "Jay" Zhang, Chair of University of Alabama at Birmingham.

In the study, described in the journal Circulation, the team tested human cardiac-muscle patches of 1.57 by 0.79 inches in size and nearly as thick as a dime, created in the lab, on large animals in a heart attack model.

Transplanting two of these patches onto the infarcted area of a pig heart significantly improved function of the heart's left ventricle, the major pumping chamber.

The patches also significantly reduced infarct size, which is the area of dead muscle, heart-muscle wall stress and heart-muscle enlargement, as well as significantly reducing apoptosis, or programmed cell death, in the scar boarder area around the dead heart muscle.

Furthermore, the patches did not induce arrhythmia in the hearts -- improper beating of the heart, too fast or too slow.

Each patch was made from a mixture of three cell types -- four million cardiomyocytes, or heart-muscle cells, two million endothelial cells -- known to help cardiomyocytes survive and function in a micro-environment -- and two million smooth muscle cells, which line blood vessels.

Each patch was grown in a three-dimensional fibrin matrix that was rocked back and forth for a week. The cells begin to beat synchronously after one day.

This mixture of three cell types and the dynamic rocking produced more heart muscle cells that were more mature, with superior heart-muscle physiological function and contractive force.

The patches resembled native heart-muscle tissue in their physiological and contractile properties, the scientists noted.

--IANS rt/umer/vm

( 322 Words)

2018-01-13-14:26:08 (IANS)

Watch News Videos

 
  LATEST COMMENTS (0)
POST YOUR COMMENT
Comments Not Available
 
POST YOUR COMMENT
 
TRENDING TOPICS
 
 
 
CITY NEWS
MORE CITIES
 
MORE HEALTH NEWS
Heart patients who walk faster hospitali...
Six-year-old Odisha girl critical after ...
Avicii's brother in Oman...
Medication use increases in newly-diagno...
Easier detection of concussions!...
Mother's early menopause affects daughte...
More...
 
INDIA WORLD ASIA
CJI should consider recusal from judicia...
Sharp decline in rail accidents seen in ...
Naroda Patiya verdict a 'victory of trut...
Was asked to contest from Badami constit...
16 Maoists killed in Maharashtra (Lead)...
Yechury re-elected CPI-M General Secreta...
More...    
 
 Top Stories
State FMs to meet on May 7 on finan... 
Indian Tigers thrash China Dragons ... 
IPL: Yadav, Kishan help Mumbai to c... 
Rahul Gandhi to launch 'Save Consti... 
Anish gets a point on second day of... 
Lazio rout Sampdoria 4-0 with brace... 
16 Maoists gunned down in Maharasht... 
Gerard's brace earns Espanyol 2-0 w...