Tuesday, October 24, 2017
News

13 new genes responsible for restless legs syndrome identified

   SocialTwist Tell-a-Friend    Print this Page   COMMENT

London | Friday, 2017 6:15:04 PM IST
 
Researchers have identified 13 new genetic variants that increased the risk of developing restless legs syndrome, a finding which may help inform potential new treatment options for the chronic condition.

People suffering from restless legs syndrome feel an overwhelming urge to move, often in conjunction with unpleasant sensations, usually in the legs.

Such people also have substantially impaired sleep, reduced overall quality of life, and increased risk of depression, anxiety disorders, hypertension, and, possibly, cardiovascular disease.

Several of the genetic variants have previously been linked to the growth and development of nerve cells -- a process known as neurogenesis -- and to changes in the formation of neuronal circuits.

These findings, published in the journal Lancet Neurology, strengthen the case for restless legs syndrome being a neurodevelopmental disorder whose origins may go back to development in the womb as well as impaired nerve cell growth in later life, the researchers noted.

"The genetic risk variants that we've discovered add more weight to the idea that this condition is related to the development of our nervous system," said Emanuele Di Angelantonio from the Helmholtz Zentrum Munchen in Germany.

"It also gives us some clues to how we may treat patients affected by the condition," Angelantonio added.

"We are convinced that the newly discovered risk loci will contribute substantially to our understanding of the causal biology of the disease," said Barbara Schormair from the varsity.

Previous studies showed a strong genetic component to the disorder and led to the discovery of six genetic variants that increased the risk of developing the condition.

For the new study, the team compared the genetic data from over 15,000 patients with more than 95,000 controls, and identified a further 13 genetic risk variants.

The new genetic findings are an important step towards developing new and improved treatment options for the patients, the researchers noted.

--IANS rt/rn

( 320 Words)

2017-10-13-17:50:08 (IANS)

Watch News Videos

 
  LATEST COMMENTS (0)
POST YOUR COMMENT
Comments Not Available
 
POST YOUR COMMENT
 
TRENDING TOPICS
 
 
 
CITY NEWS
MORE CITIES
 
MORE HEALTH NEWS
Breast cancer may be accountable for rar...
Postpartum depression less likely in win...
High thyroid hormone levels may up irreg...
Why depression raises risk of early deat...
'Selfish brains' take priority while com...
Vaping may trigger deadly lung disease l...
More...
 
INDIA WORLD ASIA
Indian Women's Hockey Team departs on Tu...
Karnataka fake stamp paper kingpin Telgi...
5th edition of National Health Writers, ...
Land scam: PCS officer Randhir Singh sac...
Software engineer arrested for murder...
Congress is 'Dramebaaz Party no. 1': BJP...
More...    
 
 Top Stories
Ronaldo named FIFA men's best playe... 
Jeremy Meeks' career caused divorce... 
New York lawmaker introduces legisl... 
Joan Rivers' letters will appear in... 
Trump denies account of solider's w... 
Spanish deputy PM says still 'a cha... 
Indian Women's Hockey Team departs ... 
5th edition of National Health Writ...