Chemists devising organic materials that mimic human tissues

Derived from carbon-based compounds, these "soft" electronic materials that make up devices like pacemakers, for instance, are valued as lightweight, flexible, easily processed alternatives to "hard" electronics components such as metal wires or silicon semiconductors.

And just as the semiconductor industry is actively developing more miniaturised transistors, so, too, are those involved with organic electronics devising ways to shrink the features of their materials, so they can be better utilised in bioelectronic applications.

Accordingly, a team of chemists at the Johns Hopkins University has created water-soluble electronic materials that spontaneously assemble themselves into 'wires,' much thinner than a human hair, reports a Hopkins press release.

"What's exciting about our materials is that they are of size and scale that cells can intimately associate with, meaning that they may have built-in potential for biomedical applications," said John D. Tovar, assistant professor of chemistry at the Hopkin's Zanvyl Krieger School of Arts and Sciences.

"Can we use these materials to guide electrical current at the nanoscale? Can we use them to regulate cell-to-cell communication as a prelude to re-engineering neural networks or damaged spinal cords? These are the kinds of questions we are looking forward to being able to address and answer in the coming years," Tovar asked.

The team used the self-assembly principles that underlie the formation of beta-amyloid plaques, which are the protein deposits often associated with Alzheimer's disease, as a model for their new material.

This raises another possibility: that these new electronic materials may eventually prove useful for imaging the formation of these plaques.

"Of course, much research has been done and is still being done to understand how amyloids form and to prevent or reverse their formation," Tovar said. "But the process also represents a powerful new pathway to fabricate nanoscale materials."

These findings appeared in a recent issue of the Journal of the American Chemical Society. st/pb/dg

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